g‑Tocotrienol to prevent breast cancer after pregnancy
Investigating the efficacy of g-Tocotrienol for the prevention of post-partum breast cancer
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11324623
This project explores whether g‑tocotrienol, a form of vitamin E, can lower the chance of developing breast cancer after pregnancy in women who have recently given birth.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11324623 on ClinicalTrials.gov |
What this research studies
This work uses specially bred mouse models to mimic how pregnancy and breastfeeding change breast cancer risk and to test whether g‑tocotrienol provides protection after delivery. Researchers will control factors such as timing and duration of lactation and compare animals with different mitochondrial backgrounds while keeping the nuclear genome the same. At the cellular level they will study stress between the endoplasmic reticulum and mitochondria to identify biological mechanisms that link lactation to cancer risk. Results from the animal work will be used to decide if g‑tocotrienol should move toward human testing.
Who could benefit from this research
Good fit: The results would most directly apply to women who have recently given birth, especially those who became pregnant after age 30 and are within the years when postpartum breast cancer risk is highest.
Not a fit: People already living with advanced metastatic breast cancer or whose cancer is unrelated to postpartum biology are unlikely to benefit from this prevention-focused work.
Why it matters
Potential benefit: If successful, this research could point to a safe supplement or biological targets to lower postpartum breast cancer risk in women.
How similar studies have performed: Laboratory studies have shown anticancer effects for tocotrienols in some settings, but using g‑tocotrienol specifically to prevent postpartum breast cancer is largely preclinical and not yet proven in people.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GERMAIN, DORIS A — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: GERMAIN, DORIS A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer