Growth Hormone's Role in Osteoarthritis
Growth hormone regulating chondrocyte metabolism for osteoarthritis development
['FUNDING_R01'] · OHIO UNIVERSITY ATHENS · NIH-11094154
This research explores how growth hormone affects joint cells, aiming to understand its connection to osteoarthritis in older adults.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO UNIVERSITY ATHENS (nih funded) |
| Locations | 1 site (ATHENS, UNITED STATES) |
| Trial ID | NIH-11094154 on ClinicalTrials.gov |
What this research studies
Many older adults experience osteoarthritis, a condition without treatments that can stop its progression. While growth hormone is approved for certain conditions, its levels naturally decrease with age, and some people consider using it to counter aging effects. However, too much growth hormone or long-term use has been linked to joint problems and pain. This project looks into the specific ways growth hormone might cause joint cell damage as we age. By understanding these mechanisms, we hope to find new ways to prevent or treat osteoarthritis.
Who could benefit from this research
Good fit: This foundational research is relevant for older adults experiencing or at risk of osteoarthritis, particularly those considering or receiving growth hormone therapy.
Not a fit: Patients whose osteoarthritis is not related to growth hormone metabolism may not directly benefit from this specific line of inquiry.
Why it matters
Potential benefit: If successful, this work could lead to new interventions and therapeutic strategies to reduce the occurrence and impact of osteoarthritis.
How similar studies have performed: Preliminary studies in mice have shown that altering growth hormone levels can affect joint degeneration, suggesting a promising avenue for further investigation.
Where this research is happening
ATHENS, UNITED STATES
- OHIO UNIVERSITY ATHENS — ATHENS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHU, SHOUAN — OHIO UNIVERSITY ATHENS
- Study coordinator: ZHU, SHOUAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.