Group O whole blood for emergency trauma transfusions
1/2 Trauma Resuscitation with Group O Whole Blood Or Products (TROOP) Trial
This project compares group O whole blood to separated blood components for people with severe traumatic bleeding who are expected to need large transfusions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11173788 on NIH RePORTER |
What this research studies
If you have a severe injury and are expected to need large amounts of blood, you would be randomly given either group O whole blood or the usual separated blood parts during resuscitation. The trial runs at multiple trauma centers and follows normal emergency care while collecting information on bleeding control, complications, and survival. Random assignment means which treatment you receive is decided by chance to allow a fair comparison. Study teams will pool results from many patients to learn which approach is safer and works better.
Who could benefit from this research
Good fit: People of any age with severe traumatic injuries who are predicted to need large-volume blood transfusions at a participating trauma center are the intended candidates.
Not a fit: People with minor injuries who are unlikely to need large transfusions, or those with medical reasons preventing receipt of group O blood, are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, this could reduce deaths and complications from traumatic bleeding by identifying whether whole blood is safer or more effective than current component therapy.
How similar studies have performed: Previous evidence mostly comes from small, observational and heterogeneous studies, so a large randomized trial like this is relatively novel.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Jansen, Jan O — University of Alabama at Birmingham
- Study coordinator: Jansen, Jan O
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.