GPLD1 and exercise: helping thinking and brain health in older adults with HIV
GPLD1: Association with Cognition and Amelioration through Exercise in Aging People with HIV
Researchers will compare blood levels of the enzyme GPLD1 and physical activity (from Fitbits/accelerometers) with changes in thinking and brain-health markers in older adults living with HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11178327 on NIH RePORTER |
What this research studies
If you join, researchers will measure GPLD1 in your blood and have you wear a Fitbit or accelerometer to track physical activity. About half of the 100 participants will take part in a supervised physical-activity program while the others continue usual care. Blood tests will also check inflammation, clotting, mitochondrial function, and markers of blood-vessel remodeling, and thinking skills will be tested before and after the activity period. The team will compare how GPLD1 and activity relate to changes in these biological markers and cognitive performance.
Who could benefit from this research
Good fit: Adults aged 21 and older living with HIV who can wear an activity tracker and provide blood samples are the ideal candidates.
Not a fit: People under 21, those without HIV, or those unable to attend clinic visits, provide blood draws, or use activity trackers are unlikely to benefit from or be eligible for this research.
Why it matters
Potential benefit: If successful, this work could point to ways to improve thinking and brain health in older people with HIV through tailored exercise programs or therapies that mimic GPLD1's effects.
How similar studies have performed: Animal and early laboratory studies suggest GPLD1 can reproduce exercise-linked brain benefits, but applying this approach to aging people with HIV is a new direction.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Ellis, Ronald J. — University of California, San Diego
- Study coordinator: Ellis, Ronald J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.