Glyphosate's effects on blood sugar regulation through gut bacteria
Glyphosate impairs glucose homeostasis via gut microbiome induced alterations to bile acid signaling
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF ARIZONA · NIH-10873735
This study is looking at how glyphosate, a common weed killer, might affect blood sugar control by changing the bacteria in our gut, and it's aimed at helping people understand the possible links to type 2 diabetes.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-10873735 on ClinicalTrials.gov |
What this research studies
This research investigates how glyphosate, a common herbicide, may disrupt glucose regulation in the body by altering the gut microbiome. The study focuses on understanding the connection between glyphosate exposure and changes in bile acid signaling, which is crucial for maintaining healthy blood sugar levels. By examining the effects of glyphosate on gut bacteria and subsequent bile acid production, the research aims to uncover potential pathways that lead to type 2 diabetes. The methodology includes animal models to assess glucose tolerance and microbiome composition following glyphosate exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for type 2 diabetes, particularly those with a history of glyphosate exposure or related environmental factors.
Not a fit: Patients who do not have any risk factors for type 2 diabetes or have already been diagnosed with advanced diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into preventing or managing type 2 diabetes by targeting gut microbiome health.
How similar studies have performed: Other research has indicated that gut microbiome alterations can significantly impact metabolic health, suggesting that this approach may yield valuable insights.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MEYER, RACHEL — UNIVERSITY OF ARIZONA
- Study coordinator: MEYER, RACHEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus