Glycosylation, metabolism, and tissue development in CDG using zebrafish
Official title: Intersection of Glycosylation and Metabolism During Tissue Development
Funded at Greenwood Genetic Center · NIH-11259641 · Data updated 2026-11-12
This grant looks at how sugar attachment to proteins and fats is controlled by metabolism in developing tissues, with a focus on congenital disorders of glycosylation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Greenwood Genetic Center NIH-funded |
| Lab location | 1 site (Greenwood, United States) |
| Project start | September 3, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $284,847 |
| NIH project number | 1R35GM161481-01 |
| Project ID | NIH-11259641 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with congenital disorders of glycosylation or related glycosylation problems may benefit from advances in understanding disease pathways and potential treatments.
✕Less likely to help
Direct treatment options are not guaranteed; outcomes depend on future translational work based on these findings.
What this research studies
Researchers will use zebrafish models to study how sugar-building blocks are made and used to coat proteins and lipids during tissue growth. By integrating biochemical methods with live imaging, the project aims to map how glucose metabolism affects glycosylation and, in turn, tissue formation. The findings could reveal why certain congenital glycosylation disorders arise and point toward potential therapeutic strategies. The work combines advanced genetic tools and cellular assays to connect metabolism, glycosylation, and development in a living organism.
Why it matters
Potential benefit: Better understanding of CDG mechanisms could guide future therapies and improve diagnosis and management for patients with glycosylation disorders.
How similar studies have gone: Prior work shows that glycosylation and metabolism are linked in development, and this zebrafish approach could extend those insights to human disease.
Where this research is happening
-
Greenwood Genetic Center
Greenwood, United States Active
Researchers
- Principal investigator: Flanagan Steet, Heather R — Greenwood Genetic Center
- Study coordinator: Flanagan Steet, Heather R
Related research
Other NIH-funded projects on the same topics.
-
How leaking lysosomes and secreted cathepsins damage cartilage and heart in lysosomal storage diseases
Researchers are looking at whether enzymes called cathepsins that leak out of lysosomes harm cartilage and heart tissue in people with lysosomal storage diseases.
-
Understanding the causes of congenital disorders of glycosylation
This study is looking at a rare genetic condition called PMM2-CDG, which affects how the body processes certain sugars, and researchers are using zebrafish to learn more about how this condition works and how it might be treated in the future.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.