Global Latinos Sequencing for Alzheimer's Disease
GLASS-AD: Global Latinos Sequencing Study for Alzheimer's Disease
This project uses whole-genome sequencing to find genetic differences linked to Alzheimer's disease in Hispanic/Latino people.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11397671 on NIH RePORTER |
What this research studies
If you join, researchers will collect a DNA sample (blood or saliva) and medical information from Hispanic/Latino participants. They will generate whole-genome sequencing data on about 6,000 people—4,000 from an existing U.S. cohort and 2,000 newly recruited participants in Peru and Bolivia. The team focuses on people with mixed European, African, and Native American ancestry to find rare and common genetic variants related to Alzheimer's. Results will be combined with other Latino datasets to improve statistical power for discovering ancestry-specific risk and protective variants.
Who could benefit from this research
Good fit: Ideal participants are Hispanic/Latino adults (including those with mixed European, African, and Native American ancestry), with or without Alzheimer's dementia, who are willing to provide DNA and health information.
Not a fit: People who are not of Hispanic/Latino ancestry or who are unwilling to provide genetic samples or medical information are unlikely to benefit directly from participation.
Why it matters
Potential benefit: If successful, this could reveal genetic risk and protective factors that improve diagnosis, risk prediction, and guide future treatments tailored to Hispanic/Latino populations.
How similar studies have performed: Large Alzheimer's sequencing efforts have found important risk genes before, but large-scale whole-genome sequencing specifically in Hispanic/Latino groups is relatively new and aims to fill a representation gap.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Tosto, Giuseppe — Columbia University Health Sciences
- Study coordinator: Tosto, Giuseppe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.