GI graft-versus-host disease biobank and gut organoid program
Core 2: Biorepository, Biomarker Analysis and GI Organoids
['FUNDING_P01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11191471
This project stores and tests blood and gut samples and grows miniature gut tissues to help people with gastrointestinal graft-versus-host disease after bone marrow transplant.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11191471 on ClinicalTrials.gov |
What this research studies
If I take part or donate samples, the team stores my blood and tissue in the MAGIC biobank using barcoded tubes linked to my records. They run biomarker tests on human and mouse samples, use strict quality-control checks, and can screen samples quickly to report results to participating sites within 24 hours. The core uses computer tools to reduce data errors and to create up-to-date control groups for single-arm clinical trials. They also grow gut organoids from patient tissue to study intestinal stem cell survival and cell-death pathways in GVHD.
Who could benefit from this research
Good fit: Ideal candidates are people who have had or are having bone marrow transplantation and who develop or are at risk for gastrointestinal graft-versus-host disease, or patients willing to donate blood or tissue samples.
Not a fit: People without a bone marrow transplant history or without GI GVHD, and those unwilling to provide samples, are unlikely to benefit directly.
Why it matters
Potential benefit: Could help researchers find faster diagnostics, choose patients for trials, and develop treatments that protect or repair the gut after GVHD.
How similar studies have performed: Biobanks and patient-derived organoids have been used successfully in other settings to discover biomarkers and study intestinal disease, so this program builds on established methods.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FERRARA, JAMES L. M. — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: FERRARA, JAMES L. M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.