Germline gene regulation by PUFs and small RNAs in cancer-related biology
Official title: Synergistic Regulation of Germline Development by PUFs and small RNAs
Funded at University of Montana · NIH-11347057 · Data updated 2026-11-12
A research project explores how germline gene regulators called PUF proteins and small RNAs work together to control fertility and development, with potential links to cancer and other diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Montana NIH-funded |
| Lab location | 1 site (Missoula, United States) |
| Project start | September 11, 2026 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $352,322 |
| NIH project number | 1R01GM164627-01 |
| Project ID | NIH-11347057 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with or at risk for infertility or cancers linked to germline regulatory pathways, or researchers seeking translational insights into germline biology.
✕Less likely to help
Individuals without fertility or germline-related cancer concerns may not directly benefit from this work.
What this research studies
This project studies how PUF proteins and small RNAs collaborate within germ granules to keep gene expression programs stable in germ cells. By using model organisms like C. elegans, the team will map how these regulators assemble with RNAs and how disruptions may lead to fertility issues and disease. The work aims to uncover the mechanisms that ensure proper germline stem cell function and transmission of genetic information across generations. Results could shed light on human infertility and cancer biology by highlighting conserved pathways. The research combines molecular biology, genetics, and imaging to understand these regulatory networks.
Why it matters
Potential benefit: If successful, findings could illuminate new targets for treating infertility and provide insights into cancer biology linked to germline regulation.
How similar studies have gone: Previous studies in model organisms support that PUFs and small RNAs regulate germline development, suggesting this approach could translate to humans.
Where this research is happening
-
University of Montana
Missoula, United States Active
Researchers
- Principal investigator: Voronina, Ekaterina — University of Montana
- Study coordinator: Voronina, Ekaterina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.