Genomics core for understanding vaccine immune responses
Genomics Core
['FUNDING_OTHER'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11481642
Using advanced genomics and immune tests, this project maps how vaccinated people and those with viral infections respond at the molecular and cellular level.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11481642 on ClinicalTrials.gov |
What this research studies
You would be asked to give blood or tissue samples before and after vaccination or during infection so researchers can profile your immune cells. Scientists will run multi-omics tests including bulk RNA sequencing, single-cell CITE-seq, CyTOF, spatial transcriptomics, and viral genomics to measure genes, proteins, and virus details. These molecular datasets will be combined with clinical information and antibody tests to look for patterns that predict how well vaccines work. The Genomics Core generates and quality-controls the data and shares it for integrated analysis across the project.
Who could benefit from this research
Good fit: Ideal participants include people receiving vaccines, people with recent viral infections (such as COVID-19), or volunteers willing to donate blood or tissue samples for immune profiling.
Not a fit: People who cannot provide biological samples, are not in vaccine or infection cohorts, or are seeking immediate clinical treatment rather than research participation may not receive direct benefit.
Why it matters
Potential benefit: This could help identify immune signatures that predict vaccine protection and guide better vaccines or personalized vaccination strategies.
How similar studies have performed: Previous studies using single-cell and serologic methods have found promising immune signatures after vaccination and infection, but integrating these multi-omics approaches is still an emerging area.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SEBRA, ROBERT — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: SEBRA, ROBERT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.