Genomics and data-analysis support for adult T‑cell leukemia/lymphoma
Core C: Informatics-Genomics-Biostats Core
Using advanced genomic and statistical methods to help researchers understand adult T‑cell leukemia/lymphoma in people with HTLV‑1.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11198134 on NIH RePORTER |
What this research studies
This core provides bioinformatics, genomics, and biostatistics services to the research team working on HTLV‑1‑related adult T‑cell leukemia/lymphoma (ATLL). It will combine multi‑omics data (DNA, RNA, epigenetics) and single‑cell analyses and apply custom computational pipelines to find patterns in patient samples and experimental models. The biostatistics team will design experiments and use models like linear mixed models and ANOVA to ensure results are statistically sound. The core will produce reproducible analyses and clear visual summaries to guide the linked projects toward potential biomarkers or therapeutic leads.
Who could benefit from this research
Good fit: Ideal candidates are people with HTLV‑1 infection or a diagnosis of adult T‑cell leukemia/lymphoma who can provide clinical samples or permit use of their clinical data in multi‑omics research.
Not a fit: Patients without HTLV‑1 infection or those who cannot or do not provide samples or data are unlikely to directly benefit from this core.
Why it matters
Potential benefit: If successful, the core's analyses could reveal new disease mechanisms, biomarkers, or therapeutic targets that lead to better diagnosis or treatments for ATLL patients.
How similar studies have performed: Other blood cancer studies using multi‑omics and advanced bioinformatics have found useful biomarkers and targets, but applying these methods specifically to ATLL is still emerging.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Griffith, Malachi — Washington University
- Study coordinator: Griffith, Malachi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.