Genomic tools to track insecticide resistance in malaria mosquitoes
Official title: Genome-based diagnostics for mapping, monitoring and management of insecticide resistance in major African malaria vectors
Funded at Tmliverpool School of Tropical Medicine · NIH-11136227 · Data updated 2026-11-12
Using DNA analysis of mosquitoes to find and follow resistance so communities in sub-Saharan Africa can use the most effective mosquito control.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tmliverpool School of Tropical Medicine NIH-funded |
| Lab location | 1 site (Liverpool, United Kingdom) |
| Project start | February 15, 2016 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $461,691 |
| NIH project number | 5R01AI116811-09 |
| Project ID | NIH-11136227 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are residents of malaria-endemic communities in East Africa, particularly sites in Uganda and Kenya where the field trials and surveillance are happening.
✕Less likely to help
People living outside malaria-endemic regions or away from the trial and surveillance sites are unlikely to receive direct benefit from this project.
What this research studies
I live in a malaria area and researchers will use whole-genome sequencing of local Anopheles mosquitoes to find genetic changes linked to insecticide resistance. They will combine these genomic results with large field trials of long-lasting insecticidal nets and attractive sugar baits in Uganda and Kenya to see how resistance affects control. The team will use functional genomics tools such as CRISPR to confirm which genetic markers cause resistance. The project aims to create a genomic surveillance system that helps national programs know when and where to switch control tools.
Why it matters
Potential benefit: If successful, this could help malaria programs pick more effective insecticides and reduce malaria cases in affected communities.
How similar studies have gone: Earlier work has identified genetic markers of resistance and trials of nets with synergists like PBO have shown public health benefits, but routine use of genome surveillance to guide control is a newer approach.
Where this research is happening
-
Tmliverpool School of Tropical Medicine
Liverpool, United Kingdom Active
Researchers
- Principal investigator: Donnelly, Martin James — Tmliverpool School of Tropical Medicine
- Study coordinator: Donnelly, Martin James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.