Genomic testing and data analysis support for glioblastoma care
Molecular Profiling and Bioinformatics
This program offers clinical-grade DNA and RNA sequencing and advanced data analysis to help guide care for people with glioblastoma who join related clinical trials.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-11184275 on NIH RePORTER |
What this research studies
If you join an affiliated clinical trial, doctors can send your tumor tissue for CLIA-certified exome and transcriptome sequencing so results can be used in clinical decision-making. The core also performs single-cell or single-nucleus RNA analyses on cells collected from the tumor bed after surgery to map tumor heterogeneity and evolution. These molecular data are combined with bioinformatics to look for signatures that suggest sensitivity or resistance to the specific therapies being tested, including novel agents in the U19 program. The core links laboratory discoveries to the clinical trials to improve how treatments are matched to individual tumors.
Who could benefit from this research
Good fit: Ideal candidates are people with glioblastoma who enroll on the City of Hope U19/Glioblastoma Translational Network clinical trials and can provide tumor tissue and consent for genomic testing.
Not a fit: Patients not enrolled in the affiliated trials, those without available tumor tissue, or those whose tumors lack actionable molecular findings are less likely to gain direct benefit.
Why it matters
Potential benefit: Patients could receive personalized molecular information that may help clinicians select targeted or experimental treatments more precisely.
How similar studies have performed: Clinical-grade tumor sequencing has informed treatment decisions in many cancers, but applying deep single-cell profiling to match new glioblastoma agents is a newer and still-developing approach.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Berens, Michael E. — Beckman Research Institute/city of Hope
- Study coordinator: Berens, Michael E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.