Genome-editing methods and their effects on the body
Genome Editing and Biological Effects Testing Component
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-11174583
This project tests genome-editing delivery methods in nonhuman primates to help develop safer gene therapies for people with genetic diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-11174583 on ClinicalTrials.gov |
What this research studies
Researchers will use nonhuman primates to try a range of viral and nonviral delivery tools and gene-editing reagents created by investigators. They will measure how well edits persist, how precise they are, and whether editing causes inflammation or immune reactions. Studies will include animals of different ages and disease models to better reflect human conditions. The team will coordinate experiments, collect and share data, and prioritize work to speed safe translation to human treatments.
Who could benefit from this research
Good fit: Ideal candidates for future clinical trials would be adults with genetic disorders that can be treated by somatic cell genome editing.
Not a fit: Patients whose conditions are not caused by changeable genes or who require germline (heritable) editing are unlikely to benefit from this work.
Why it matters
Potential benefit: If successful, this work could make future gene-editing treatments safer and more effective for people with genetic diseases.
How similar studies have performed: Related preclinical and some early human gene-editing trials have shown promise, but testing delivery and safety in primates remains a crucial and still-developing step.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SEGAL, DAVID J — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: SEGAL, DAVID J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.