Genetics resource for frontotemporal dementia
Genetics Core
This program looks for and maps genetic changes linked to frontotemporal dementia using DNA from people in the ALLFTD network.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11198460 on NIH RePORTER |
What this research studies
From a patient's perspective, the Genetics Core collects and analyzes DNA from thousands of ALLFTD participants to find genetic causes of frontotemporal lobar degeneration (FTLD). They use broad genetic testing and deep profiling to identify known and new mutations and to group people with similar genetic signatures. The core shares analyzed genetic data with ALLFTD projects and other researchers to improve links between genes, brain imaging, and biomarkers. This work helps explain unexplained cases and guides better matching of patients to future trials and treatments.
Who could benefit from this research
Good fit: Ideal candidates are people diagnosed with frontotemporal dementia or related syndromes and family members who can provide DNA samples for genetic study.
Not a fit: People without FTLD-type dementia or those seeking immediate clinical treatment (rather than genetic characterization) are unlikely to get direct benefit from this genetics resource.
Why it matters
Potential benefit: If successful, this could help identify genetic causes of someone's dementia and make it easier to match patients to the most appropriate clinical trials or future gene-targeted therapies.
How similar studies have performed: Genetics consortia have already found major FTLD genes and this core has previously generated genetic data from thousands of participants, so the approach builds on proven methods.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Rademakers, Rosa — Mayo Clinic Rochester
- Study coordinator: Rademakers, Rosa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.