Genetics of extreme depression treated with ECT
1/2 Genetics at an extreme: an efficient genomic study of individuals with clinically severe major depression receiving ECT
Researchers are looking for genetic differences linked to very severe major depression in people receiving electroconvulsive therapy so doctors can better match treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10926819 on NIH RePORTER |
What this research studies
If you have very severe major depression and have had or are considering ECT, this project collects DNA and clinical information from people like you across centers worldwide. Scientists will compare genetic data to find variants tied to severe illness and to whether patients improve or have cognitive side effects after ECT. The aim is to find markers that could help identify who may need ECT and who is most likely to benefit. Participating may involve sharing medical records, providing a saliva or blood sample, and allowing researchers to use treatment and outcome data.
Who could benefit from this research
Good fit: Adults with clinically severe or treatment-resistant major depressive disorder who have received, are currently receiving, or are planned to receive ECT are the ideal candidates.
Not a fit: People with mild or moderate depression who are not candidates for ECT or those without a major depressive disorder diagnosis are unlikely to benefit from participating.
Why it matters
Potential benefit: Could help clinicians predict who will benefit from ECT and shorten the time patients spend trying ineffective treatments.
How similar studies have performed: Large genome-wide studies have found many genetic links to depression, but focused genetics work on severely ill, ECT-treated patients is newer and may offer clearer signals.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Zandi, Peter P. — Johns Hopkins University
- Study coordinator: Zandi, Peter P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.