Genetics of breast cancer risk in Latin American and Hispanic/Latina women
Latin America Genomics of Breast Cancer Risk Study (LAGENO-BCR)
This project looks at how inherited genetic differences change breast cancer risk for Latin American and Hispanic/Latina women.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11179412 on NIH RePORTER |
What this research studies
Researchers will combine DNA and health information from tens of thousands of women with and without breast cancer across 11 Latin American countries and the U.S. diaspora. They will use genome-wide analysis to find genetic variants that are more common or protective in people with Indigenous American and other ancestries. The team will update polygenic risk scores and build risk models that account for ancestry and geography. The larger combined sample is meant to find signals missed in smaller studies and make predictions more accurate for Latino/Hispanic populations.
Who could benefit from this research
Good fit: Ideal candidates are women of Latin American or Hispanic/Latina heritage, with or without a breast cancer diagnosis, who can provide a DNA sample and health information.
Not a fit: People who are not of Latin American or Hispanic/Latina ancestry or whose breast cancer risk is unrelated to inherited genetics may not see direct benefit from these results.
Why it matters
Potential benefit: If successful, this work could give Latin American and Hispanic/Latina women more accurate genetic risk estimates to guide screening and prevention.
How similar studies have performed: Large genome-wide studies in European-ancestry groups have improved risk scores, and smaller Hispanic/Latina studies have already found unique protective variants, so this larger effort builds on promising prior work.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Fejerman, Laura — University of California at Davis
- Study coordinator: Fejerman, Laura
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.