Genetics Core for Alzheimer’s and related dementias biomarkers
Official title: Genetics Core
Funded at Northern California Institute/res/edu · NIH-11395224 · Data updated 2026-11-12
This grant supports a genetics core that helps scientists discover and validate biomarkers for Alzheimer’s disease and related dementias by linking brain tissue findings with clinical data.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 30, 2004 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $546,460 |
| NIH project number | 5U19AG024904-19 |
| Project ID | NIH-11395224 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients or donors who participate in or contribute to brain donation programs and ADRD research.
✕Less likely to help
Patients not enrolled in brain donation or archival tissue studies may not directly benefit.
What this research studies
The Genetics Core partners with the ADNI Neuropathology Core to create reliable, tissue-based reference data that connect clinical diagnoses, fluid biomarkers, and brain imaging to definitive neuropathology. It focuses on collecting and storing brain donations, standardizing neuropathologic assessments, and enabling biomarker research using ADNI tissue. By validating clinical and biomarker findings against gold-standard pathology, the core aims to improve how ADRD is diagnosed and how trials select participants. The work builds a foundation for future biomarker-driven therapies and better understanding of disease mechanisms.
Why it matters
Potential benefit: If successful, this core could improve accuracy of ADRD diagnoses and accelerate development of effective biomarkers and treatments.
How similar studies have gone: ADNI’s prior neuropathology work has established groundwork for reliable biomarker validation, with ongoing enhancements in brain donation and data integration.
Where this research is happening
-
Northern California Institute/res/edu
San Francisco, United States Active
Researchers
- Principal investigator: Saykin, Andrew J — Northern California Institute/res/edu
- Study coordinator: Saykin, Andrew J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.