Genetics and molecular profiling to improve care for Crohn’s disease and ulcerative colitis
Official title: Precision IBD via genetics and genomics: integrating International and multi-omic datasets, expanding studies in diverse populations, and defining mechanisms of unmet clinical needs in IBD
Funded at Icahn School of Medicine at Mount Sinai · NIH-11144944 · Data updated 2026-11-12
Combining genetic and single-cell molecular data to better understand and help people with Crohn’s disease and ulcerative colitis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 30, 2002 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,600,000 |
| NIH project number | 5U24DK062429-26 |
| Project ID | NIH-11144944 on NIH RePORTER |
Who could benefit from this research
✓Could help
People diagnosed with Crohn’s disease or ulcerative colitis who are willing to contribute genetic samples and clinical information to a research consortium.
✕Less likely to help
People without IBD or those who cannot or will not provide samples or clinical data are unlikely to benefit directly from this project.
What this research studies
This project brings together genetic and single-cell molecular data from people with inflammatory bowel disease to find links between genes and disease features. The data coordinating center collects and standardizes clinical and sequencing information from international genetics research centers and maps sequence data from thousands of patient-derived samples. Teams will integrate DNA, ATAC, and transcriptome single-cell datasets and analyze differences between Crohn’s disease and ulcerative colitis and across diverse populations. The combined resource will be shared to support further research and may guide the development of tests or targeted treatments.
Why it matters
Potential benefit: May enable more precise diagnoses, reveal new treatment targets, and support personalized care options for people with IBD.
How similar studies have gone: Previous large international genetics consortia have identified many IBD risk genes, but combining multi-omic single-cell data across diverse populations is a newer approach with promising but still emerging results.
Where this research is happening
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Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Cho, Judy H. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Cho, Judy H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.