Genetic study of Crohn's disease across populations and treatments
Official title: Montreal-Boston Collaborative GRC
Funded at Montreal Heart Institute · NIH-11371160 · Data updated 2026-11-12
Researchers are studying how genetic factors and biological markers influence Crohn’s disease across diverse populations and how patients respond to targeted therapies.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Montreal Heart Institute NIH-funded |
| Lab location | 1 site (Montreal, Canada) |
| Project start | September 30, 2002 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $483,450 |
| NIH project number | 5U01DK062432-26 |
| Project ID | NIH-11371160 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with Crohn’s disease who are starting or changing molecularly-targeted therapies and who can provide genetic and blood samples.
✕Less likely to help
Some patients may not experience improved treatment response or may not contribute to the biomarker analyses.
What this research studies
This grant supports a collaboration between Montreal and Boston to understand why Crohn’s disease develops and behaves differently in people from various backgrounds. It uses genetic data, blood tests, metabolomics, and single-cell RNA sequencing to map risk factors and track patients as they start targeted treatments over a year. The goal is to learn why some patients respond differently to therapy and to identify markers that predict outcomes. Results could help tailor treatments to individual patients in the future.
Why it matters
Potential benefit: Could lead to personalized treatment plans and better outcomes for people with Crohn’s disease.
How similar studies have gone: Prior IBD genetic studies have identified variants influencing disease risk and treatment response, with later work refining these findings across populations.
Where this research is happening
-
Montreal Heart Institute
Montreal, Canada Active
Researchers
- Principal investigator: Rioux, John D. — Montreal Heart Institute
- Study coordinator: Rioux, John D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.