Genetic sequencing and sample support for immune system disorders
Sequencing and sample core: genetic errors of immunity
['FUNDING_P01'] · WASHINGTON UNIVERSITY · NIH-11316963
Advanced DNA sequencing and a shared sample resource are used to find genetic causes of immune disorders that can lead to infections, autoimmunity, allergy, inflammation, or cancer.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11316963 on ClinicalTrials.gov |
What this research studies
This project collects blood and other samples from people and families with unexplained immune problems and missing genetic diagnoses. A central core performs high-throughput DNA sequencing and provides bioinformatics support to search for rare or complex genetic changes and to share data and samples with researchers. The team also studies why some family members with the same mutation get very sick while others have little or no symptoms. Findings will help improve diagnosis and enable more personalized care in the future.
Who could benefit from this research
Good fit: Ideal candidates are people with recurrent infections, unexplained autoinflammation, autoimmunity, severe allergy, or suspected inherited immune disorders, especially in families with variable symptoms among relatives.
Not a fit: People whose immune issues are clearly non-genetic, who cannot provide samples, or who decline genetic testing are unlikely to benefit from this effort.
Why it matters
Potential benefit: If successful, this could help more patients receive accurate genetic diagnoses, guide personalized treatments, and inform family testing and counseling.
How similar studies have performed: Previous sequencing efforts have already identified hundreds of genes causing immune disorders, and this core builds on those successful approaches to tackle the remaining undiagnosed and hard-to-interpret cases.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOGUNOVIC, DUSAN — WASHINGTON UNIVERSITY
- Study coordinator: BOGUNOVIC, DUSAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers