Genetic Risk and Development of Serious Mental Illness Across Life Stages
Official title: Genetic Risk for Serious Mental Illness and Development
Funded at University of Washington · NIH-11541068 · Data updated 2026-11-12
This project looks at how genetic risk helps shape when and how serious mental illnesses emerge from childhood through adulthood.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $143,771 |
| NIH project number | 3R01MH127165-05S1 |
| Project ID | NIH-11541068 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with ADHD and related conditions across a broad age range, including children, adolescents, and adults, who may be at risk for serious mental illness.
✕Less likely to help
Individuals without the specified age range or no relation to at-risk genetic profiles may not benefit from this research.
What this research studies
Researchers will explore how genetic risk factors connect with the development of serious mental illnesses like schizophrenia, bipolar disorder, and severe depression across different ages. The study uses clinical staging to identify early markers and track how symptoms and biology unfold over time. By examining genetic profiles and developmental trajectories, the project aims to find better targets for early interventions that could alter illness pathways. Participants may include individuals across a wide age range to capture changes from youth into adulthood. The work could lead to more precise understanding of who is at risk and when interventions might be most effective.
Why it matters
Potential benefit: If successful, the work could improve early identification and personalized intervention strategies for people at risk of serious mental illnesses.
How similar studies have gone: Previous genetic and clinical-staging research has shown promise in linking risk profiles to illness trajectories, but further validation is needed.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Forsyth, Jennifer Katherine — University of Washington
- Study coordinator: Forsyth, Jennifer Katherine
Related research
Other NIH-funded projects on the same topics.
-
Making genetic testing more accessible to the public
This study is all about making it easier for people at risk of certain cancers, like breast, ovarian, and colon cancers, to get genetic testing, so we can find out what helps them access these important services and understand how they can benefit from them.
-
Breast cancer diagnosis in low-resource settings using millifluidics and fast digital imaging in Ghana
A new project will test a fast, low-cost way to diagnose breast cancer at the point of care in Ghana using small-batch fluidics and direct digital imaging.
-
Binaural Hearing and Speech in Noise in Children
This project explores how children hear speech in noisy classrooms using how the two ears work together to see if binaural processing differences explain why some kids struggle more than others.
-
Neural circuits that control pain aversion in the brain
Researchers are exploring how a specific brain area helps people feel and avoid pain, with potential to lead to better pain treatments.
-
United World Antiviral Research Network (UWARN)
A collaborative, international effort is testing new virus surveillance and evolution ideas to help people living with HIV and communities in LMICs stay safer from current and emerging viruses.
-
HF endotypes in heart failure using ethical multi-modal AI and molecular data
A patient-friendly project that uses advanced AI and multiple kinds of health data to identify distinct heart failure subtypes that could guide personalized care.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.