Genetic mutations causing a type of arthritis linked to calcium crystals
Official title: Mutations in Osteoprotegerin Cause Calcium Pyrophosphate Deposition Disease
Funded at Clement J. Zablocki VA Medical Center · NIH-11098726 · Data updated 2026-11-12
This study is looking at how certain genetic changes might cause calcium pyrophosphate deposition disease, a type of arthritis that affects older adults and veterans, with the goal of finding new ways to treat this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clement J. Zablocki VA Medical Center NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | January 1, 2019 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01BX004454-07 |
| Project ID | NIH-11098726 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults, particularly veterans, who have been diagnosed with calcium pyrophosphate deposition disease.
✕Less likely to help
Patients with arthritis not related to calcium pyrophosphate crystals or those without the identified genetic mutations may not benefit from this research.
What this research studies
This research investigates calcium pyrophosphate deposition disease (CPDD), a common form of arthritis characterized by the accumulation of calcium pyrophosphate crystals in the joints. The focus is on understanding how specific genetic mutations, particularly in the osteoprotegerin gene, contribute to the development of this disease, especially in older adults and veterans. By studying these mutations, researchers aim to identify new therapeutic targets that could lead to effective treatments for this currently untreatable condition. The research involves analyzing genetic data and clinical outcomes in affected patients to better understand the disease mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for calcium pyrophosphate deposition disease, improving the quality of life for affected patients.
How similar studies have gone: Previous studies have shown promise in understanding genetic factors in arthritis, suggesting that this approach could yield valuable insights and potential breakthroughs.
Where this research is happening
-
Clement J. Zablocki VA Medical Center
Milwaukee, United States Active
Researchers
- Principal investigator: Rosenthal, Ann K — Clement J. Zablocki VA Medical Center
- Study coordinator: Rosenthal, Ann K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.