Genetic footprints of past infections in humans and primates
Genomic signatures of primate-pathogen interactions
Researchers are searching DNA from people and primates for signs that past infections shaped our genes, which may help explain differences in infection risk today.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Utah State Higher Education System--University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11175354 on NIH RePORTER |
What this research studies
This project uses large-scale DNA data and new computational tools to find genomic regions shaped by interactions with pathogens. The team will generate and analyze sequence data from under-studied populations (including the Arabian Peninsula) and compare human and non-human primate genomes. They will look at different types of genetic change, from single-letter mutations to larger structural variants and gene copy differences, and use population-genetics methods to time and trace adaptive events. The work combines sequencing, data analysis, and evolutionary modeling to map where infections have left lasting marks on genomes.
Who could benefit from this research
Good fit: People willing to contribute DNA or health information—especially individuals from the Arabian Peninsula or other under-sampled ancestry groups—would be ideal participants or data contributors.
Not a fit: This is basic and genomic research, so people seeking immediate clinical treatment or therapy are unlikely to see direct personal benefit.
Why it matters
Potential benefit: If successful, this work could reveal genetic factors that influence who is more or less susceptible to infectious diseases and point to targets for future tests or treatments.
How similar studies have performed: Previous population-genomic studies have identified infection-related genes, but this project applies newer methods and adds under-studied populations and primate comparisons for novel insight.
Where this research is happening
Salt Lake City, United States
- Utah State Higher Education System--University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Leffler, Ellen — Utah State Higher Education System--University of Utah
- Study coordinator: Leffler, Ellen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.