Genetic factors influencing lung disease related to airway cells
Official title: Genetic variants that affect the airway epithelium to drive obstructive lung disease
Funded at Brigham and Women's Hospital · NIH-11060015 · Data updated 2026-11-12
This study is looking at how certain genes might affect lung cells and their reaction to things like cigarette smoke, which could help us understand different types of COPD and find better treatments for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $797,363 |
| NIH project number | 5R01HL166992-02 |
| Project ID | NIH-11060015 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a genetic predisposition to COPD or those who have been exposed to environmental pollutants.
✕Less likely to help
Patients without any genetic variants associated with airway epithelial response or those not suffering from obstructive lung diseases may not benefit from this research.
What this research studies
This research investigates how specific genetic variants affect the airway epithelium, which may lead to obstructive lung diseases like COPD. By analyzing human airway epithelial cells from individuals with different genetic backgrounds, the study aims to identify how these genetic differences influence the cells' response to pollutants such as cigarette smoke. The researchers will utilize advanced techniques like whole genome genotyping and RNA sequencing to uncover the relationship between genetic variants and the development of chronic inflammation in the lungs. This could help in understanding the subtypes of COPD and tailoring more effective treatments.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments for patients with obstructive lung diseases.
How similar studies have gone: Previous research has shown promising results in understanding genetic influences on lung diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Tesfaigzi, Yohannes — Brigham and Women's Hospital
- Study coordinator: Tesfaigzi, Yohannes
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.