Genetic factors affecting how ADHD medication works
Carboxylesterase 1 Genetic Variation and Methylphenidate in ADHD
['FUNDING_R01'] · UNIVERSITY OF FLORIDA · NIH-10462578
This study is looking at how differences in a specific gene affect how well people with ADHD respond to the medication methylphenidate (MPH), so we can help tailor treatments to work better for each individual.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-10462578 on ClinicalTrials.gov |
What this research studies
This research investigates how genetic variations in the carboxylesterase 1 (CES1) enzyme influence the metabolism of methylphenidate (MPH), a common medication for ADHD. By analyzing the genetic profiles of ADHD patients, the study aims to identify which individuals may respond better to MPH or experience adverse effects. The approach includes measuring blood concentrations and assessing clinical responses to the medication. This could lead to more personalized treatment plans for ADHD patients based on their genetic makeup.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with ADHD who are prescribed methylphenidate.
Not a fit: Patients who do not have ADHD or are not prescribed methylphenidate may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective ADHD treatments tailored to individual genetic profiles.
How similar studies have performed: Previous research has shown promising results in understanding genetic influences on medication responses, suggesting potential for success in this area.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARKOWITZ, JOHN S — UNIVERSITY OF FLORIDA
- Study coordinator: MARKOWITZ, JOHN S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.