Genetic changes that alter Type 1 diabetes
Project 2 - Verification and Molecular Mechanisms of T1D Modifier Mutations
['FUNDING_P01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11096037
This project looks at whether specific genetic mutations change how Type 1 diabetes starts and progresses using engineered animal and lab models to help people with or at risk for T1D.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11096037 on ClinicalTrials.gov |
What this research studies
This project focuses on 'modifier' mutations that change Type 1 diabetes risk and course in NOD mouse models. Researchers will recreate candidate mutations with CRISPR in mouse strains and compare the mutant and normal forms of the affected proteins. They will tag proteins in mice, perform protein pulldowns and mass spectrometry, and run cell experiments to map altered interactions and signaling. The aim is to link particular genetic changes to molecular mechanisms that could point to new prevention or treatment targets.
Who could benefit from this research
Good fit: People with Type 1 diabetes or those with a family history or high genetic risk would be most relevant to follow this research or participate in related future studies.
Not a fit: People with type 2 diabetes or unrelated conditions are unlikely to receive direct benefit from this mouse- and lab-based genetic work.
Why it matters
Potential benefit: If successful, the work could reveal new molecular targets that might be used to prevent or slow the onset of Type 1 diabetes.
How similar studies have performed: Related genetic-engineering and proteomics studies in animal models have identified disease mechanisms, though turning those discoveries into human treatments has been limited so far.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BEUTLER, BRUCE A — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: BEUTLER, BRUCE A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.