Genetic Changes in Brain Conditions
STRUCTURAL VARIATION IN NEUROLOGICAL DISEASE
['FUNDING_OTHER'] · BAYLOR COLLEGE OF MEDICINE · NIH-10991399
This work explores how complex changes in our genes can lead to brain conditions like Alzheimer's disease and autism.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10991399 on ClinicalTrials.gov |
What this research studies
Our genes contain instructions for how our bodies work, and sometimes these instructions have complex rearrangements that can cause neurological diseases. We are looking closely at these genetic changes, which can be more complicated than previously thought, involving extra or missing pieces of DNA in unusual patterns. By understanding how these complex genetic changes happen, we hope to uncover the root causes of conditions such as Alzheimer's disease, autism, and other brain disorders. This foundational work aims to shed light on the mechanisms behind these diseases.
Who could benefit from this research
Good fit: This foundational genetic research is relevant to adults aged 21 and older who are affected by or have a family history of neurological conditions like Alzheimer's disease or autism.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention may not find direct benefit from this basic science research at this stage.
Why it matters
Potential benefit: If successful, this research could lead to a deeper understanding of neurological diseases, potentially paving the way for improved diagnostic tools and new treatment strategies.
How similar studies have performed: Previous research has shown that genomic rearrangements are a common cause of neurological diseases, and this work builds upon those findings by exploring their complex nature.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LUPSKI, JAMES R. — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: LUPSKI, JAMES R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Autistic Disorder