Genetic and immune markers for recurrent kidney disease after transplant
Genetics and Immune Predictors for Recurrent Glomerular Diseases in the Kidney Allograft
This project looks at DNA and blood immune markers to help predict and understand when immune-driven kidney diseases come back in people with a kidney transplant.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11372006 on NIH RePORTER |
What this research studies
If you join, researchers will collect clinical information, blood samples, donor and recipient DNA, and biopsy tissue from people who have had a kidney transplant. They are building a large, multi-center group of transplant patients with and without recurrent glomerular disease to compare findings. The team will use genetic risk scores and antibody tests that worked in native-kidney disease to see if they help explain or predict recurrence in transplanted kidneys. Results could help doctors tailor monitoring and treatment after transplant to reduce graft loss.
Who could benefit from this research
Good fit: Ideal candidates are people who have received a kidney transplant and either had a primary immune-mediated glomerular disease (like IgA nephropathy, membranous nephropathy, or podocytopathy) or are being followed for possible recurrence.
Not a fit: People whose kidney failure was caused by non-immune conditions (for example diabetic kidney disease or vascular disease) and who have no history or risk of recurrent glomerular disease are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could help identify transplant patients at higher risk of disease recurrence so they can get closer monitoring or more personalized treatment to protect the kidney.
How similar studies have performed: Genetic risk scores and certain blood antibody tests have shown usefulness in native-kidney glomerular diseases, but applying these approaches to predict recurrence after transplant is relatively new.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Batal, Ibrahim — Columbia University Health Sciences
- Study coordinator: Batal, Ibrahim
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.