Genes that keep the eye lens clear
Transcriptional control of gene expression in the lens
Researchers are exploring how the genes Mafg, Mafk, and Nrf2 help the eye lens form and stay clear to better understand causes of cataract.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Delaware NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11251235 on NIH RePORTER |
What this research studies
This project uses a gene-discovery tool (iSyTE) and laboratory models to find which genes control lens development and transparency. Scientists turn off or change the Mafg, Mafk, and Nrf2 genes in mice to see how the lens is affected. They compare gene activity using RNA sequencing to spot pathways that go wrong when these genes are disrupted. The goal is to map the molecular steps that lead to cataract so future tests or therapies can target them.
Who could benefit from this research
Good fit: People with age-related cataract or inherited lens disorders could be future candidates for clinical work informed by these findings.
Not a fit: Patients needing immediate cataract treatment such as lens surgery are unlikely to see direct benefit from this basic laboratory research right now.
Why it matters
Potential benefit: If successful, the work could identify new targets or markers for preventing or treating cataract.
How similar studies have performed: Prior genetic and animal studies have linked these genes to lens problems, but combining bioinformatics with specific knockout models to define the regulatory network is relatively new.
Where this research is happening
Newark, UNITED STATES
- University of Delaware — Newark, United States (Active)
Researchers
- Principal investigator: Lachke, Salil — University of Delaware
- Study coordinator: Lachke, Salil
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.