Genes that influence type 2 diabetes and related measures
Targeted Genetic Analysis of T2D and Quantitative Traits
Using genetic data and detailed liver cell profiles to find which genes and cell types drive type 2 diabetes in adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11391484 on NIH RePORTER |
What this research studies
This project combines large genetic studies with single-nucleus multiome mapping (RNA plus ATAC-seq) to profile gene activity and regulatory DNA in individual liver cells. Researchers will link previously identified diabetes-associated genetic signals to specific liver cell types and cell states, with a focus on liver lipid metabolism. By pinpointing the exact genes, regulatory changes, and cell types involved, they aim to explain how genetic differences increase diabetes risk. Results could point to new drug targets or biomarkers for people with adult-onset diabetes.
Who could benefit from this research
Good fit: Adults with type 2 diabetes or related metabolic conditions who can provide clinical information or biospecimens (blood or, in some settings, liver tissue) would be the best fit.
Not a fit: People without type 2 diabetes, those whose condition is driven mainly by non-genetic factors, or those unable to provide samples are unlikely to receive direct benefit.
Why it matters
Potential benefit: Could identify specific genes, cell types, and regulatory mechanisms that lead to new treatments or tests for type 2 diabetes.
How similar studies have performed: Prior GWAS and bulk-tissue QTL work has found candidate genes and regulatory links, and emerging single-cell/multiome studies have begun to refine cell-type-specific effects though the approach is still developing.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Mohlke, Karen L. — Univ of North Carolina Chapel Hill
- Study coordinator: Mohlke, Karen L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.