Genes that influence how THC changes behavior and bodily responses
Official title: Identification of gene variants mediating the behavioral and physiological response to THC
Funded at University of Tennessee Health Sci Ctr · NIH-11323899 · Data updated 2026-11-12
This project looks at how natural genetic differences affect how the body and behavior respond to high‑potency cannabis in a mouse model, with potential implications for people who use cannabis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | July 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $725,759 |
| NIH project number | 5R01DA056523-04 |
| Project ID | NIH-11323899 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to direct patient participation for this grant since it is a mouse-based study; however, findings may inform human risk understanding in the future.
✕Less likely to help
No direct patient involvement is expected in this grant.
What this research studies
Researchers will use a pharmacogenomic screen in the BXD mouse family to find gene variants that change CB1 receptor levels and signaling after a high dose of THC. The study builds on prior findings that different mouse strains show different acute responses to THC and may point to genetic factors that influence risk. By mapping genetic influences on cannabinoid signaling, the work aims to reveal biological pathways that contribute to behavioral and physiological reactions to THC. The results could inform future work on personalized approaches to cannabis use and health risks. All work is planned in mice, with a focus on understanding mechanisms that could relate to humans in the context of high-potency cannabis exposure.
Why it matters
Potential benefit: If successful, this research could identify genetic factors that shape THC responses, potentially guiding personalized risk assessments and informing safer cannabis policies and therapies.
How similar studies have gone: Preliminary work showed strain differences in THC responses and identified candidate QTLs, suggesting a promising path forward.
Where this research is happening
-
University of Tennessee Health Sci Ctr
Memphis, United States Active
Researchers
- Principal investigator: Mulligan, Megan Kathleen — University of Tennessee Health Sci Ctr
- Study coordinator: Mulligan, Megan Kathleen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.