Genes that help people recover from hepatitis B
Human Genetic determinants of HBV recovery
This project looks at how genetic differences help people with and without HIV clear hepatitis B infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11047665 on NIH RePORTER |
What this research studies
You're invited to learn how genes might explain why some people clear hepatitis B while others develop chronic infection. Researchers are comparing genome-wide data from thousands of people who recovered from HBV to those with chronic HBV, with special focus on African-ancestry individuals and people living with HIV. They will combine genetic analyses with viral sequencing and laboratory follow-up to identify specific variants and host–virus interactions. Findings aim to point to biological targets that could guide new treatments or strategies to achieve a functional cure.
Who could benefit from this research
Good fit: Ideal candidates include people who have recovered from past HBV infection and people with chronic HBV, including those living with HIV and individuals of African ancestry.
Not a fit: People without any history of hepatitis B or whose liver disease is caused by non-viral conditions are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this work could reveal genetic targets to guide new treatments or vaccines that help more people clear hepatitis B.
How similar studies have performed: Previous genome-wide studies in Asian populations have identified genetic links to HBV clearance, but large-scale studies in African-ancestry and HIV-positive groups are limited.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Thomas, David L — Johns Hopkins University
- Study coordinator: Thomas, David L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.