Genes that help Listeria survive inside human cells
Identification and Characterization of Genes Required for Listeria monocytogenes Cytosolic Survival
Researchers are looking for bacterial genes that let Listeria live inside human cells to help reduce illness from listeriosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11331258 on NIH RePORTER |
What this research studies
This project uses the Listeria bacterium to find which bacterial genes are needed for it to survive inside the interior of host cells. Scientists will run genetic screens on Listeria and use lab models of infected cells to see which genes control cell wall stress responses and metabolic adaptations. They will map protein modifications and study key bacterial proteins that help make and remodel the cell wall during cytosolic survival. The work is done in laboratory bacterial and cell models at the University of Wisconsin–Madison to learn how these findings might guide future treatments.
Who could benefit from this research
Good fit: People affected by or at higher risk for listeriosis—such as pregnant people, older adults, and those with weakened immune systems—would be the eventual population to benefit or to consider for future clinical work.
Not a fit: Because this is lab-based basic research, someone currently sick with listeriosis should not expect direct or immediate personal benefit from this project.
Why it matters
Potential benefit: If successful, this research could point to new ways to block Listeria survival and lead to treatments or drugs that reduce severe listeriosis.
How similar studies have performed: Related laboratory studies have already identified regulators like the PASTA kinase PrkA that affect Listeria survival, but translating these findings into treatments remains at an early stage.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Sauer, John-Demian — University of Wisconsin-Madison
- Study coordinator: Sauer, John-Demian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.