Genes that help brain cells survive over a lifetime
Genetic control mechanisms of long-term neuronal survival
Researchers are looking at how certain genes and RNA splicing help neurons stay alive, with the goal of helping people with Alzheimer's and related memory disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-11322164 on NIH RePORTER |
What this research studies
This project will look inside neurons to find the gene switches and RNA processing steps that keep brain cells alive as we age. The team will focus on specific splicing elements they have already identified and test how changing those elements affects neuronal survival in lab models. Their plan includes three linked aims to map these elements, track how they change during development, and measure the effects of altering splicing on cell death pathways. Findings could point to new biological targets for slowing neuron loss in Alzheimer's and similar conditions.
Who could benefit from this research
Good fit: People with Alzheimer's disease, mild cognitive impairment, or at high risk for neurodegenerative dementia would be the most relevant candidates for future related sample donations or clinical trials.
Not a fit: Individuals without neurodegenerative brain conditions or those seeking immediate treatment changes are unlikely to gain direct benefit from this basic laboratory research.
Why it matters
Potential benefit: If successful, this work could reveal targets for therapies that help neurons survive longer and slow cognitive decline in Alzheimer's disease.
How similar studies have performed: Prior basic research has linked alternative RNA splicing to neuron function and survival, but turning those findings into human treatments remains largely unproven.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Zheng, Sika — University of California Riverside
- Study coordinator: Zheng, Sika
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.