Genes that guide kidney development
Transcription factors in kidney development
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11292385
This project looks at how the protein Eya1 and its partner proteins control the genes that build kidney filtering units during development.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11292385 on ClinicalTrials.gov |
What this research studies
From a patient's perspective, researchers are tracing how Eya1 teams up with other proteins to turn genes on or off while kidneys form. They will map where these proteins bind DNA, identify the genes they regulate, and study how those interactions influence nephron progenitor cells. The team uses molecular biology methods, genomics (like ChIP-seq), and cell and tissue experiments to build a detailed map of these control networks. Because many Eya1 targets overlap with genes linked to Wilms tumor, the work also looks for connections to childhood kidney cancer.
Who could benefit from this research
Good fit: People or families affected by congenital kidney malformations or Wilms tumor could be the most relevant for related future studies or sample donation efforts.
Not a fit: Patients with unrelated conditions, such as typical adult-onset kidney disease without developmental origins, are unlikely to see direct benefit from this basic developmental biology research.
Why it matters
Potential benefit: If successful, this work could reveal why some babies are born with kidney formation problems and point to new targets for preventing or treating congenital kidney defects and related childhood kidney cancers.
How similar studies have performed: Previous lab work by the team has already identified Eya1 partners and binding sites, so this project builds on solid preclinical findings rather than starting from scratch.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XU, PIN-XIAN — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: XU, PIN-XIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.