Genes behind fibromuscular dysplasia and related artery problems
Genomic and Functional Studies of Dysplasia-Associated Arterial Diseases
['FUNDING_OTHER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11308334
This project looks for gene changes that cause fibromuscular dysplasia and other dysplasia-related artery problems and studies how those changes affect blood vessels.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11308334 on ClinicalTrials.gov |
What this research studies
Researchers will analyze the genetic information from people with fibromuscular dysplasia (FMD) and related arterial conditions to map the range of gene changes involved. They will use laboratory models to see how specific gene variants change the behavior and structure of vascular smooth muscle and its surrounding matrix. The team aims to sort out which genetic changes actually cause disease versus those of uncertain importance. Findings will be used to explain why some people develop narrowing, aneurysm, or tearing of arteries and to guide future tests or treatments.
Who could benefit from this research
Good fit: People diagnosed with fibromuscular dysplasia or with familial/early-onset arterial dysplasia (for example unexplained arterial stenosis, aneurysm, or dissection) would be ideal candidates.
Not a fit: People whose artery problems are due to atherosclerosis or clearly unrelated causes, or those seeking an immediate clinical treatment rather than genetic information, are unlikely to benefit directly from this research.
Why it matters
Potential benefit: If successful, this work could improve genetic diagnosis, help explain why arteries weaken or narrow in FMD, and point toward new targets for treatment or prevention.
How similar studies have performed: Previous studies have found genetic links in some FMD cases, but combining comprehensive genetic mapping with detailed lab testing of variants is a newer and less-tested approach.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GANESH, SANTHI K — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: GANESH, SANTHI K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Arterial Disorder