Generating molecular data from biological samples to understand health disparities
Official title: Omics Core
Funded at Mayo Clinic Jacksonville · NIH-11075361 · Data updated 2026-11-12
This study is looking at blood and brain samples from different groups of people to find out how certain health conditions change our biology, which could help doctors create better treatments for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | March 15, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,401,656 |
| NIH project number | 5U19AG074879-03 |
| Project ID | NIH-11075361 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals from African American, Latino American, and non-Hispanic white backgrounds who are part of the specified cohorts.
✕Less likely to help
Patients who do not belong to the targeted racial and ethnic groups or those who are not part of the specified cohorts may not receive benefit from this research.
What this research studies
This research focuses on collecting and analyzing various biological samples, such as blood and brain tissue, from diverse cohorts, including African American, Latino American, and non-Hispanic white populations. By utilizing advanced techniques like RNA sequencing and proteomics, the study aims to uncover molecular changes associated with different health conditions. Patients will benefit from the comprehensive data collection that links biological markers to clinical outcomes, potentially leading to better-targeted treatments. The Omics core will ensure that the data is harmonized and well-coordinated across multiple research sites.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of health disparities among different racial and ethnic groups.
How similar studies have gone: Previous research has shown success in using multi-omics approaches to uncover health disparities, indicating that this methodology is promising.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Allen, Mariet — Mayo Clinic Jacksonville
- Study coordinator: Allen, Mariet
Related research
Other NIH-funded projects on the same topics.
-
Carotid artery treatment for people with artery narrowing who don’t have symptoms
A large, international study is testing whether intensive medical care plus either carotid surgery or carotid stenting improves outcomes for people with high-grade carotid artery narrowing who have not yet had symptoms.
-
Antibiotic Allergy: Types, Triggers, and How they Work
This grant aims to better understand why certain antibiotics trigger immediate allergic reactions and how to improve testing and diagnosis for patients with suspected antibiotic allergies.
-
Lipid-gene Profiles in Septic ARDS
A Mayo Clinic team is studying how dysfunctional HDL in sepsis relates to different ARDS patient outcomes, aiming to find features that could guide better treatment.
-
APOE4 and brain lymphatic drainage in Alzheimer's disease
This NIH grant investigates how the APOE4 gene affects the brain’s lymphatic system and its role in Alzheimer’s disease, with potential implications for people at risk.
-
Tumor Susceptibility Gene 101: a microglial therapy approach to protect memory in Alzheimer’s disease
A Mayo Clinic team is studying a protein called TSG101 in brain immune cells to slow or prevent cognitive decline in Alzheimer’s disease.
-
ABCA7 loss of function and Alzheimer's disease
This grant examines how changes in ABCA7, a brain lipid transporter, may influence Alzheimer's disease risk and progression in people.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.