Gene therapy to improve movement in Parkinson's disease
Gene therapy targeting striatal dysfunction for Parkinson’s disease
This study is exploring a new gene therapy that could help improve movement problems in people with Parkinson's disease by targeting specific brain receptors, and it's currently being tested in monkeys before it can be used in humans.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11032815 on NIH RePORTER |
What this research studies
This research investigates a novel gene therapy approach aimed at addressing motor abnormalities in Parkinson's disease by targeting specific receptors in the brain. The study focuses on the role of striatal projection neurons and how their dysfunction, caused by the loss of dopamine cells, leads to movement issues. By using gene knockdown techniques to reduce the activity of certain glutamate receptors, the researchers aim to restore normal function and alleviate symptoms. The research involves preclinical testing in non-human primates to evaluate the effectiveness of this therapy before potential application in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease who experience significant motor symptoms.
Not a fit: Patients with Parkinson's disease who do not exhibit motor symptoms or have advanced stages of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved motor function and quality of life for patients with Parkinson's disease.
How similar studies have performed: Other research has shown promise in using gene therapy approaches for neurological conditions, suggesting potential success for this novel strategy.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Papa, Stella M — Emory University
- Study coordinator: Papa, Stella M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.