Gene switches that change cartilage in osteoarthritis
Epigenetic Regulation in Cartilage Tissue
This project aims to protect joint cartilage in people with osteoarthritis by changing the activity of a gene regulator (Dnmt3b) and an enzyme called ABAT.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11314578 on NIH RePORTER |
What this research studies
The team studies how an epigenetic regulator called Dnmt3b and the enzyme ABAT control cartilage health in osteoarthritis. They use mouse models, human cartilage cells and donated tissue samples, DNA methylation and gene-expression sequencing, and gene-delivery tools to increase or decrease these targets. They also test whether blocking ABAT with drugs or reducing its levels protects cartilage and reduces joint inflammation. Results from the lab and animal work will guide plans for future tissue-based studies and possible clinical approaches.
Who could benefit from this research
Good fit: People with osteoarthritis or early cartilage damage who can donate tissue samples or join future clinical studies would be ideal candidates.
Not a fit: People without joint disease or those whose joints have already been replaced are unlikely to benefit directly from this research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that slow cartilage loss, reduce pain, and delay or prevent joint replacement in people with osteoarthritis.
How similar studies have performed: Prior lab and mouse studies from the same team showed that changing Dnmt3b and ABAT affects cartilage health, but translating these findings into human therapies is still new.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: O'keefe, Regis J — Washington University
- Study coordinator: O'keefe, Regis J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.