Gene editing to target HIV hiding in the body and brain
Broad-spectrum HIV gene editing strategies in peripheral and brain reservoirs
['FUNDING_R01'] · DREXEL UNIVERSITY · NIH-11256727
This work builds gene‑editing tools intended to remove or disable hidden HIV for people living with HIV, including virus hiding in the brain.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DREXEL UNIVERSITY (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11256727 on ClinicalTrials.gov |
What this research studies
This project develops CRISPR‑Cas9 guide RNAs designed to find and cut HIV DNA that persists in infected cells across body compartments, including the brain. The team uses a patented computational pipeline to pick guides that work across many HIV strains while minimizing the chance of cutting human genes. Guides are tested in cells and tissue/animal models to measure how well they edit viral DNA, how safe they are (off‑target effects), and whether they can reach brain reservoir cells. Findings are intended to support future clinical approaches for people living with HIV.
Who could benefit from this research
Good fit: People living with HIV who are stable on antiretroviral therapy and interested in experimental cure research would be the most likely candidates for future participation.
Not a fit: People without HIV or those who are not suitable for gene‑therapy approaches (for example with uncontrolled infections or certain medical conditions) would not be expected to benefit.
Why it matters
Potential benefit: If successful, this approach could reduce or eliminate latent HIV reservoirs and move toward a functional cure that reduces or ends the need for lifelong therapy.
How similar studies have performed: CRISPR approaches have reduced HIV DNA in cells and animal models, but no CRISPR‑based cure has yet been proven safe and effective in people.
Where this research is happening
PHILADELPHIA, UNITED STATES
- DREXEL UNIVERSITY — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WIGDAHL, BRIAN — DREXEL UNIVERSITY
- Study coordinator: WIGDAHL, BRIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus