Gene editing to heal diabetic skin wounds
Official title: Cell Specific Gene Editing to Close Diabetic Wounds
Funded at University of Pittsburgh at Pittsburgh · NIH-11052464 · Data updated 2026-11-12
This study is looking at how certain genes might affect the healing of skin ulcers in people with diabetes, and if you have diabetic ulcers, you could help by taking part in some genetic testing to see how your genes might play a role in your healing process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | April 1, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $505,708 |
| NIH project number | 5R01DK135447-03 |
| Project ID | NIH-11052464 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetic skin ulcers who are experiencing chronic wound healing issues.
✕Less likely to help
Patients without diabetes or those who do not have chronic skin wounds may not benefit from this research.
What this research studies
This research focuses on understanding how specific genetic variations affect the healing of diabetic skin ulcers, which are common and serious complications for people with diabetes. By analyzing genetic factors, particularly single nucleotide variations (SNVs), the study aims to identify how these variations influence the healing process. The researchers will investigate the role of the NOTCH1 gene and its associated SNVs in promoting wound closure. Patients with diabetic ulcers may have the opportunity to contribute to this research through genetic testing and analysis.
Why it matters
Potential benefit: If successful, this research could lead to new gene-based therapies that significantly improve healing outcomes for patients with diabetic wounds.
How similar studies have gone: While the specific approach of targeting SNVs in diabetic wound healing is novel, similar genetic research has shown promise in other areas of wound healing.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Sen, Chandan K — University of Pittsburgh at Pittsburgh
- Study coordinator: Sen, Chandan K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.