Gamma delta T cells and their role in inflammation related to HIV and aging
Official title: Gamma delta T cells promote inflammation in aviremic HIV infection and normal aging
Funded at Boston University Medical Campus · NIH-10939760 · Data updated 2026-11-12
This study is looking at how certain immune cells called gamma delta T cells might play a role in inflammation for people with HIV and those who are aging, especially in connection with Alzheimer's disease, to help us understand how gut health and immune responses could affect brain health and memory.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2020 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $412,500 |
| NIH project number | 3R01AG065050-05S1 |
| Project ID | NIH-10939760 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living with HIV, older adults, and those experiencing symptoms of Alzheimer's disease or related dementias.
✕Less likely to help
Patients who are not living with HIV or do not have age-related cognitive decline may not benefit from this research.
What this research studies
This research investigates how gamma delta T cells contribute to inflammation in individuals with HIV and those experiencing normal aging, particularly in relation to Alzheimer's disease. The study aims to understand the unique characteristics of these T cells and their activation in the gut, which may lead to systemic inflammation and cognitive decline. By analyzing blood and brain tissue samples, the researchers hope to uncover the connections between immune responses, gut health, and neurodegenerative conditions. This could provide insights into the mechanisms driving dementia and related disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing inflammation and cognitive decline in patients with HIV and age-related dementias.
How similar studies have gone: Previous research has shown promising results in understanding the role of immune cells in neuroinflammation, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Snyder-Cappione, Jennifer E — Boston University Medical Campus
- Study coordinator: Snyder-Cappione, Jennifer E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.