Gamma delta T cells and their role in inflammation related to HIV and aging
Official title: Gamma delta T cells promote inflammation in aviremic HIV infection and normal aging
Funded at Boston University Medical Campus · NIH-10862859 · Data updated 2026-11-12
This study is looking at how certain immune cells called gamma delta T cells might influence inflammation and gut health in people with HIV who have their virus under control, as well as in older adults, to see how they could be linked to age-related issues like osteoporosis, stroke, and dementia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2020 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $718,155 |
| NIH project number | 5R01AG065050-05 |
| Project ID | NIH-10862859 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals aged 65 and older who are HIV-positive and have achieved viral suppression.
✕Less likely to help
Patients who are not HIV-positive or those who are younger than 65 years old may not benefit from this research.
What this research studies
This research investigates how gamma delta T cells contribute to inflammation in individuals with HIV who have achieved viral suppression, as well as in the aging population. It focuses on the relationship between these immune cells and age-related diseases, particularly how they may affect intestinal health and overall inflammation. By examining the role of these T cells in the gut, the research aims to understand their impact on conditions such as osteoporosis, stroke, and dementia in older adults. The study employs a combination of clinical assessments and laboratory analyses to explore these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to improved management of inflammation-related health issues in older adults living with HIV.
How similar studies have gone: Previous research has shown that targeting immune responses can lead to significant improvements in health outcomes for aging populations, suggesting potential success for this approach.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Snyder-Cappione, Jennifer E — Boston University Medical Campus
- Study coordinator: Snyder-Cappione, Jennifer E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.