Frontotemporal Degeneration Coordination Core
Administrative Core
This program helps scientists work together to find biomarkers and causes of frontotemporal degeneration so people with FTD can get clearer diagnoses and better future treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11265585 on NIH RePORTER |
What this research studies
This coordination core brings together teams working from nanoscale lab experiments to lifetime exposure data to pinpoint biomarkers that separate TDP‑43 from tau-driven FTD. The core supports standardized collection and sharing of human brain tissue, genetic and clinical data, and other biospecimens across participating sites. It manages data, methods, advisory committees, and quality control to speed up validation and comparison of candidate biomarkers. If you have FTD or are willing to donate samples or share clinical information, your contribution could help link lab findings to patient outcomes and guide future tests and therapies.
Who could benefit from this research
Good fit: People diagnosed with frontotemporal degeneration, primary progressive aphasia, or related early-onset dementias who are willing to share clinical data or donate biospecimens are the best matches for this effort.
Not a fit: People without FTD or those seeking an immediate symptom-relief therapy are unlikely to get direct clinical benefit from this coordination and biomarker-focused work.
Why it matters
Potential benefit: Could lead to earlier and more accurate diagnoses and enable treatments aimed at the specific biology (TDP‑43 vs tau) causing a person's FTD.
How similar studies have performed: Tissue- and biomarker-based programs have produced useful tests in Alzheimer's and some progress in FTD, but reliable TDP‑43–specific clinical markers are still limited and this program aims to advance that area.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Mcmillan, Corey T — University of Pennsylvania
- Study coordinator: Mcmillan, Corey T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.