Following up on vitamin C and smoking in pregnancy to understand children's lung health
Official title: Continued follow-up of the Vitamin C and Smoking in Pregnancy (VCSIP) cohorts through the ECHO consortium, focus on Echo-wide protocols, respiratory outcomes, airway function, and epigenetic changes
Funded at Oregon Health & Science University · NIH-11319112 · Data updated 2026-11-12
This project continues to follow children whose mothers smoked during pregnancy, and some who also took vitamin C, to understand how these factors affect their lung health over time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | September 21, 2016 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $1,012,944 |
| NIH project number | 4UH3OD023288-10 |
| Project ID | NIH-11319112 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include existing participants in the ECHO Cohort, particularly those from the original VCSIP cohort, and new pregnant participants.
✕Less likely to help
Patients who are not pregnant or are not part of the existing ECHO or VCSIP cohorts may not directly benefit from participation in this specific follow-up.
What this research studies
We are continuing our involvement in the ECHO Program to extend our understanding of how maternal smoking during pregnancy, and vitamin C supplementation, impact children's lung health. This long-term follow-up involves existing participants from our original study and will also include new pregnant participants. By combining data from many maternal-child groups, we can look at how different environmental factors affect health outcomes. We are especially interested in how maternal smoking affects lung development and disease risk in children, and how vitamin C might help, while also looking at related genetic changes.
Why it matters
Potential benefit: If successful, this work could help us better understand how maternal smoking and vitamin C intake during pregnancy affect children's long-term lung health, potentially leading to new prevention strategies.
How similar studies have gone: Previous work by this group has shown that supplemental vitamin C may help decrease the effects of smoking during pregnancy on infant lung function.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Mcevoy, Cynthia T — Oregon Health & Science University
- Study coordinator: Mcevoy, Cynthia T
Related research
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Vitamin C in Pregnancy to Protect Kids’ Lungs from Smoking Effects
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Vitamin C and Smoking in Pregnancy: long-term lung health and airway changes in children
This grant follows children and families over many years to understand how maternal smoking and vitamin C during pregnancy affect a child’s lungs and airway health, including epigenetic changes.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.