Following different types of type 2 diabetes over time using blood and genetic tests
Longitudinal omics-based trajectories of type 2 diabetes subtypes: the T2D Heterogeneity Consortium
This project uses medical information plus blood-based tests like genetics and other molecular markers to find and track different kinds of type 2 diabetes in adults and predict how each type may change over time.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11172551 on NIH RePORTER |
What this research studies
If you take part, researchers will use your medical records and collect blood samples to run genetic and other 'omics' tests. They will combine clinical measurements (like blood sugar and complications) with these molecular data to define distinct diabetes subtypes. The team will follow people over years to build models that predict who may develop complications or respond to specific treatments. Results aim to help tailor future care based on the subtype a person has.
Who could benefit from this research
Good fit: Adults with new-onset or established type 2 diabetes or people with prediabetes who can share medical records and provide blood samples are ideal candidates.
Not a fit: People with type 1 diabetes, unrelated medical conditions, or those unwilling to provide biospecimens or clinical data may not receive direct benefits from this project.
Why it matters
Potential benefit: If successful, this work could enable more precise diabetes diagnoses and personalized treatments that reduce complications and premature death.
How similar studies have performed: Prior research has shown reproducible diabetes subgroups and genetic clusters, but a coordinated, long-term multi-omic approach to predict individual disease courses is relatively new.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Manning, Alisa Knodle — Massachusetts General Hospital
- Study coordinator: Manning, Alisa Knodle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.