Fluoride's impact on children's tooth development and health
Official title: Fluoride Effects on Dental Craniofacial Development and Pathophysiology.
Funded at Nova Southeastern University · NIH-11485603 · Data updated 2026-11-12
This grant investigates how fluoride affects growing teeth in children, aiming to understand how overexposure could cause dental and bone issues later in life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nova Southeastern University NIH-funded |
| Lab location | 1 site (Fort Lauderdale-Davie, UNITED STATES) |
| Project start | September 22, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $580,256 |
| NIH project number | 1R01DE036564-01 |
| Project ID | NIH-11485603 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable (preclinical/animal and molecular studies); no direct patient enrollment is described in the abstract.
✕Less likely to help
The study may not provide direct benefits to individuals during the research phase, particularly outside of future therapeutic avenues.
What this research studies
Researchers will study how fluoride interferes with tooth development and the aging process, focusing on phosphatase enzymes and their role in odontogenesis. The project uses laboratory studies to uncover molecular mechanisms and looks at differences across ages to explain why younger and older teeth may respond differently. Findings could lead to new targets for preventing fluoride toxicity and potentially inform public health guidelines on fluoride use.
Why it matters
Potential benefit: If successful, this work could lead to therapies that mitigate fluoride toxicity and safer, evidence-based fluoride guidelines to protect children's dental and overall health.
How similar studies have gone: Previous work in this lab has shown fluoride can cause dentin-pulp lesions and enamel changes, supporting a plausible mechanism for fluoride-related pathophysiology.
Where this research is happening
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Nova Southeastern University
Fort Lauderdale-Davie, United States Active
Researchers
- Principal investigator: Suzuki, Maiko — Nova Southeastern University
- Study coordinator: Suzuki, Maiko
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.