Flu vaccine responses and infection risk in people over 75
Leveraging an ongoing longitudinal study of influenza vaccination to define immune signatures of response and risk of infection in older adults >75
['FUNDING_U01'] · JOHNS HOPKINS UNIVERSITY · NIH-11237598
This project looks at immune responses to seasonal flu vaccines in adults over 75 to find patterns linked to protection or risk of infection.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11237598 on ClinicalTrials.gov |
What this research studies
You would be joining a long-term group of community-dwelling adults over 75 who have given blood samples and health information across multiple flu seasons. Researchers will use advanced lab tests on stored and new blood samples — including cell-level profiling, RNA sequencing, and antibody measurements — to map immune cell types and flu-specific responses. They will compare people who had breakthrough flu infections to those who remained protected and consider factors like frailty and repeated yearly vaccination. The team aims to identify immune patterns that explain who is most likely to be protected or to get sick despite vaccination.
Who could benefit from this research
Good fit: Ideal candidates are community-dwelling adults aged 75 or older who receive seasonal flu vaccination and can provide blood samples and basic health information.
Not a fit: People younger than 75, those unable to give blood samples, or residents of institutions not included in the cohort are unlikely to be eligible or directly benefit from this specific project.
Why it matters
Potential benefit: If successful, this work could help identify older adults who need stronger vaccines or extra protection during flu season.
How similar studies have performed: Related immune-profiling studies have helped explain vaccine responses in younger adults, but applying these high-resolution methods to long-running samples from adults over 75 is relatively new.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LENG, SEAN XIAO — JOHNS HOPKINS UNIVERSITY
- Study coordinator: LENG, SEAN XIAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.