Fine-grained protein function labeling powered by a community of practice
Official title: Fine-grained Annotation of the Protein Universe through a Community of Practice
Funded at Iowa State University · NIH-11416315 · Data updated 2026-11-12
A broad, community-driven effort to improve computer-based predictions of what proteins do in the body, using shared tools and open software.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa State University NIH-funded |
| Lab location | 1 site (Ames, United States) |
| Project start | September 25, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $432,961 |
| NIH project number | 5R01GM145937-03 |
| Project ID | NIH-11416315 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not a direct patient trial, but improves resources used in human biology and disease research.
✕Less likely to help
No direct patient participation or benefits in this grant.
What this research studies
This grant supports sustaining and expanding a community of scientists who predict protein functions from genomic data. It focuses on improving algorithms, curating annotations, and making software open-source and containerized so researchers worldwide can reuse it. The project aims to move toward continuous, up-to-date protein function predictions integrated with UniProt and Gene Ontology frameworks. The work is computational and collaborative, with a goal of better understanding proteins in health and disease. Participants may include biocurators, bioinformaticians, and developers who contribute to community resources.
Why it matters
Potential benefit: If successful, patients could benefit from faster, more accurate protein function annotations that underpin disease research and new therapies.
How similar studies have gone: Previous CAFA challenges have driven improvements in protein function prediction and community collaboration.
Where this research is happening
-
Iowa State University
Ames, United States Active
Researchers
- Principal investigator: Friedberg, Iddo — Iowa State University
- Study coordinator: Friedberg, Iddo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.